脊柱关节退变外泌体与自噬串扰的研究进展△（开放获取）

(Open Access) Advances in the study of exosomes and autophagy crosstalk in spine and joint degenerations

摘要:

椎间盘退变（intervertebral disc degeneration, IDD） 和骨关节炎(osteoarthritis, OA） 是临床常见的脊柱关节退行性疾病，严重影响患者的生活质量，目前尚无有效的根治方法。不同来源的外泌体与自噬的串扰能够延缓IDD 和OA 的进展，其作用机制涉及抑制相关细胞凋亡和保护细胞外基质等。本文通过归纳近年来相关文献，综述了外泌体与自噬的串扰在脊柱关节退行性疾病诊疗中的应用现状，发现自噬是治疗脊柱关节退行性疾病的新兴靶点，外泌体中包含骨重建所需的多种生物活性物质，二者的相互串扰可进一步提高IDD 和OA 的疗效，以期为今后该领域的研究提供参考。

Abstract:

Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are common spine and joint degenerative diseases, which seri-ously affect people's quality of life. Currently, there is no effective radical treatment. The crosstalk between exosomes and autophagy of differ-ent origin can delay the progression of IDD and OA, and its mechanism involves inhibiting apoptosis and protecting extracellular matrix. Byreviewing relevant literature in recent years, this paper described the application status of exosomes and autophagy in the diagnosis and treat-ment of spinal and articular degenerative diseases, and found that autophagy might be an emerging target for the treatment of osteoarticulardegenerative diseases. Exosomes contain a variety of bioactive substances required for bone reconstruction, and the mutual interference ofthe two can further improve the efficacy of IDD and OA. It is expected to provide reference for future research in this field.