Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of neurovascular pedicle flap combinedwith antibiotic calcium sulfate in treatment of infectious wounds around the ankle. [Methods] From April 2016 to June 2022, a total of 21patients with infectious wounds around the ankle were treated by neurovascular pedicle flap combined with antibiotic calcium sulfate. Thesaphenous nerve and posterior tibial artery perforators around the wound was marked by high-frequency color doppler ultrasound preopera-tively. After debridement, the skin margin on one side of the flap was firstly cut to expose the saphenous nerve and posterior tibial arteryperforators near the flap axis and rotation point. After that, the flap was freed with subcutaneous fascia tissue about 1.5~2.0 cm in wide onboth sides of the flap axis retained. The flap was transferred to cover the wound by an open tunnel. The prepared antibiotic calcium sulfateparticles were filled into the cavity below the flap. Subsequently, the saphenous nerve was anastomosed end-to-end with the nerve stumpsat donor site under microscope. The flap donor site was sutured directly or repaired by intermediate split thickness skin graft harvested fromthe thigh. [Results] All 21 patients had flaps and skin grafts at donor site survived uneventfully with the incisions at the donor site healed inexcellent grade, and were followed up for (15.2±4.9) months in a mean. All patients returned to normal life without infection recurrence, hadappearance of the flaps looked good with a wear-resistant and soft texture. At the latest follow-up, the function of the affected ankle andfoot was marked as excellent in 10, good in 10, and fair in 1, with excellent and good rate of 95.2%. [Conclusion] This neurovascular pedi-cle flap combined with antibiotic calcium sulfate is a good option for treating infectious wounds at the distal leg and the ankle and foot withadvantages of simple procedure and good outcome.