Abstract:[Objective] To compare percutaneous transforaminal endoscopic discectomy (PTED) versus quadrant channel discectomy(QCD) in the treatment of lumbar disc herniation. [Methods] A retrospective study was conducted on 78 patients who had single-level discherniation removed surgically in our department in 2022. According to preoperative doctor-patient communication, 40 patients were treatedwith PTED, while other 38 patients were treated with QCD. The perioperative, follow-up and imaging data of the two groups were com-pared. [Results] All patients in both groups had corresponding operations performed successfully without serious complications. Althoughthe PTED was significantly greater than the QCD group in terms of operative time [(65.7±6.4) min vs (34.2±6.7) min, P=0.027] and the expo-sure number of fluoroscopy [(6.8±1.0) times vs (2.4±1.0) times, P=0.004], the former was significantly less than the latter regarding to inci-sion length [(0.8±0.2) cm vs (2.3±0.2) cm, P<0.001], intraoperative blood loss [(31.6±10.2) ml vs (54.8±11.4) ml, P=0.004] and postopera-tive bed rest time [(2.0±0.6) days vs (3.5±0.5) days, P<0.001]. As time went by, the VAS scores of low back pain and leg pain, as well asODI score in both groups were significantly decreased (P<0.05), whereas which were not statistically significant between the two groups atany time points accordingly (P>0.05). As for imaging, the spinal canal occupying rate significantly reduced (P<0.05), while the interverte-bral height and lumbar lordotic angle remained unchanged significantly in both groups after operation compared with those preoperatively(P>0.05). At any corresponding time points, there were no statistically significant differences in imaging indicators between the two groups(P>0.05). [Conclusion] The clinical consequence of the two techniques on lumbar disc herniation is comparable. By comparison, the PT-ED, despite of taking longer operation time and more intraoperative fluoroscopy times, has considerately less trauma, which facilitates earli-er ambulation and faster recovery over the QCD.