Abstract:[Objective] To introduce the surgical technique and initial clinical results of oblique lateral interbody fusion combined withendoscopic decompression for L5S1 herniation complicated with stenosis. [Methods] After general anesthesia, the patient was placed in a lat-eral position on the operating table, and the projection of the intervertebral space on the left side of the body surface was fluoroscopicallyidentified and marked. Computer-assisted navigation scanning and registration were performed in a single position. A skin incision wasmade along the projection of the body surface, and the three layers of abdominal muscles were bluntly separated until the retroperitonealspace was reached. The intervertebral space was confirmed by navigation, and a channel and blade were installed along the guide pin to re-tract and protect the iliac vessels. Intervertebral space was treated through the channel, and then direct decompression of the ventral aspectof the canal was endoscopically performed through the OLIF channel. A suitable interbody cage was implanted in the intervertebral spaceand screw-plate system was placed, finally the incision was closed in layers. [Results] All patients had operation performed smoothly withan average surgical time of (300.2±63.7) min, intraoperative blood loss of (240.4±33.2) ml, ambulation time of (54.4±12.2) hours, and hospi-tal stay of (14±3.2) days. At the latest follow-up lasted for 24 months, the pain visual analogous scale (VAS), ODI score, intervertebralheight, foraminal height, and sagittal diameter of the spine canal were significantly improved compared to those preoperatively. [Conclu-sion] This oblique lateral interbody fusion combined with endoscopic decompression for L5/S1 herniation complicated with stenosis take ad-vantages of direct decompression and the minimally invasive fusion, and achieve satisfactory primary clinical consequence.