Abstract:[Objective] To investigate the clinical efficacy of endoscopic debridement combined with continuous lavage and drainagefor thoracolumbar infection. [Methods] A retrospective study was done on 34 patients who had thoracolumbar infection lesion with or with-out abscess formation treated by abovesaid methods in our center from January 2019 to October 2022. The clinical, laboratory and imagingdocuments were evaluated. [Results] All patients were successfully operated without neurovascular injury and other complications, whilewith the average operative time of (120.3±31.4) min and blood loss of (31.2±13.5) ml. Compared with those preoperatively, the VAS score[(6.2±0.7), (3.1±1.2), P＜0.001] and ODI score [(57.4±6.7), (20.4±5.8), P＜0.001] were significantly reduced at the last follow-up. In addi-tion, the WBC, CRP and ESR significantly decreased over time (P＜0.05). As for imaging, the local kyphotic Cobb angle remained un-changed significantly (P＞0.05), while the intervertebral height [(7.7±1.6) mm, (4.7±3.0) mm, P＜0.001] significantly decreased, and the le-sions state [active/static/healed, (30/4/0), (18/0/16), P＜0.001] improved significantly at the last follow-up compared with those preoperative-ly. [Conclusion] The endoscopic debridement combined with continuous lavage and drainage does achieve satisfactory clinical conse-quence for thoracolumbar infection with or without abscess formation at different locations.