Abstract:[Objective] To compare the clinical efficacy of arthroscopic repair of type IV medial meniscal ramp lesion with suture hook (SH) versus Fast-fix (FF). [Methods] A retrospective study was conducted on 45 patients who received arthroscopic surgery for anterior cruciate ligament (ACL) tear combined with type IV medial meniscal ramp lesion from January 2016 to October 2020. All patients underwent ACL reconstruction with autologous hamstring tendon, however, 21 cases of them had medial meniscal ramp lesion repaired by using SH, and 24 cases were by using FF based on the preoperative doctor-patient communication. The perioperative period, follow-up and imaging results were compared between the two cohorts. [Results] All patients in both groups had operation done successfully without complications such as vascular and nerve injury during the operation. The SH group consumed significantly longer operation time [(91.2±10.6) min vs (62.5±8.4) min, P<0.001], and total length of incision [cm (5.9±0.5) vs (5.1±0.6) cm, P<0.001] than the FF group, but the former spend significantly less hospitalization cost than the latter [(3.4±0.3) ten-thousand yuan vs (4.3±0.7) ten-thousand yuan, P<0.001]. There were no significant differences in ramp lesion length, number of meniscal stitches, walking time, incision healing grade and hospital stay between the two groups (P>0.05). All patients were followed up from 36 months to 72 months, and there was no significant difference between the two groups in time to resume full-weight bearing activity (P>0.05). The knee joint space tenderness, McMurray sign, pivot shift sign, knee flexionextension ROM, IKDC and Lysholm scores significantly improved in both groups 1 year after surgery and at the last followup compared with those preoperatively (P<0.05), which were not statistically significant between the two groups at any time points accordingly (P>0.05). As for imaging, the meniscus injury grade and posterior tibial plateau bone marrow edema were significantly improved in both groups 1 year after surgery (P<0.05), and no statistical significance in the above indexes was noted between the two groups at any corresponding time points (P>0.05). One year after surgery, MRI showed that the healing rate of the lesion was of 90.5% in SH group, while 87.5% in the FF group, with no statistical significance between them (P>0.05). [Conclusion] Arthroscopic repair of type IV medial meniscal ramp lesion with both suture hook and Fast-fix do obtain satisfactory clinical consequences.