Abstract:[Objective] To investigate the clinical consequence of locking plate combined with titanium cable cerclage for fixation of Vancouver type B1 periprosthetic femoral fractures. [Methods] A retrospective study was done on 9 patients who had Vancouver type B1 periprosthetic femoral fractures treated by locking plate combined with titanium cable cerclage in our hospital from August 2021 to March 2023. The clinical and imaging document were evaluated. [Results] All the patients had revision performed successfully with no vascular and nerve injuries and other serious complications during the operation, whereas with the average operation time of (95.1±15.8) min, intraoperative blood loss of (622.2±272.9) ml, and hospital stay of (12.9±4.8) days, and were followed up for (15.3±5.3) months in an average. With time from that before revision, 3 months preoperatively to the latest follow-up, the VAS [(8.7±1.2), (4.8±1.1), (0.7±0.7), P＜0.001] significantly reduced, while the hip flexion-extension range of motion (ROM) [(10.3±6.0)°, (88.2±8.3)°, (111.4±6.0)°, P＜0.001], internal-external rotation ROM [(3.8±2.5)°, (20.4±4.0)°, (39.6±3.2)°, P＜0.001] and the Harris score [(21.3±7.8), (72.1±5.3), (89.3±7.7), P＜0.001] significantly increased. As for imaging, the femoral alignment [case, excellent/good/fair/poor, (0/0/2/7), (9/0/0/0), (9/0/0/0), P＜0.001] and the femoral prosthetic position [case, excellent/good/fair/poor, (0/0/1/8), (9/0/0/0), (9/0/0/0), P＜0.001] significantly improved over time. [Conclusion] The locking plate and titanium cable cerclage used for fixation of Vancouver type B1 periprosthetic femoral fractures achieve satisfactory shortterm outcomes, with the hip function of the affected limb recovered well.