Abstract:[Objective] To investigate the clinical outcome of rehabilitation and nursing care for prevention of acute bone loss in periop- erative period of hip fracture in the elderly. [Methods] A total of 95 patients who were undergoing hip arthroplasty (HA) for hip fracture from July 2022 to June 2023 were included in this study, and were divided into anti-loss group (47 cases) and routine group (48 cases) by random number table method. The corresponding rehabilitation and nursing care were given, and the clinical and blood test results of the two groups were compared. [Results] All patients in both groups had HA performed smoothly. The anti-loss group proved significantly superior to the routine group in terms of first time of getting out of bed [(41.6±5.6) h vs (54.5±8.7) h, P 0.001] and the maximum postoperative walking distance [(88.6±9.5) m vs (67.8±8.9) m, P 0.001]. The VAS and Harris scores of the two groups were significantly improved over time (P<0.05). The anti-loss group was also significantly better than the routine group regarding to VAS score [(2.3±1.0) vs (3.0±1.2), P 0.004] 24 hours postoperatively, and [(1.1±0.8) vs (2.4±1.1), P<0.001] at discharge, as well as Harris score [(60.4±6.8) vs (54.5±9.4), P<0.001] at discharge, [(76.6±4.7) vs (74.2±6.0), P 0.029] 4 weeks after operation and [(86.4±6.4) vs (81.8±5.8), P 0.001] 12 weeks postoperatively. As for lab test, the bone gzlutamyl protein (BGP), N-terminal propeptide of type I collagen (PINP) and beta c-terminal cross-linked telopeptides of typeⅠ collagen (β-CTX) were significantly increased 4 and 12 weeks after operation compared with those preoperatively (P<0.05). Although there were no significant differences in the above lab test items between the two groups before surgery (P>0.05), the anti-loss group had significantly higher BGP and PINP, while significantly lower β-CTX than the routine group 4 and 12 weeks after surgery (P<0.05). [Conclusion] The rehabilitation and nursing care for prevention of acute bone loss do reduce occurrence of perioperative acute bone loss, relieve postoperative pain and promote functional recovery in perioperative period of HA for hip fracture in elderly