Abstract: [Objective] To investigate the clinical efficacy of carpal shoot through view (CSTV) and dorsal tangential view (DTV) of fluoroscopy during open reduction and internal fixation (ORIF) with plate for distal radius fractures. [Methods] From January 2019 to January 2023, 50 patients with distal radius fractures were included in this study. According to the preoperative doctor-patient communication, the patients were divided into CSTV group and DTV group, with 25 cases in each group. Clinical and imaging data were compared between the two groups. [Results] There were no significant differences in operation time, incision length and intraoperative blood loss between the two groups (P>0.05). At the last follow-up lasted for a mean of (12.7±3.4) months, there were no significant differences in wrist extension-flexion range of motion (ROM), radio-ulnar deviation ROM and Gartland-Werley scores between the two groups (P>0.05). In term of imaging, the fluoroscopy times in CSTV group were significantly less than that in DTV group [(1.9±0.8) vs (2.7±1.2), P=0.008]. There was no a significant difference in the detection rate of penetrating screw between the two groups (P>0.05), and no penetrating screw was missed in both groups. [Conclusion] Both CSTV and DTV positions can effectively detect the screw penetrating the dorsal cortex of the distal radius during ORIF of distal radius fracture with palmar plate, however, the fluoroscopy times in CSTV group is less than that in DTV group.