椎间盘退变体内与体外模型的研究进展△

Advances in in vivo and in vitro models of intervertebral disc degeneration

摘要:

椎间盘退变 （intervertebral disc degeneration, IDD） 是退变性脊柱疾病的关键病理过程，其治疗对医生来说仍然是一个挑战。椎间盘相关病变已成为亟待解决的全球性健康问题。目前对于人体椎间盘退行性变的研究仍存在一定的局限性，尚没有一种动物模型可以全面模拟 IDD 的病理状况和复杂机制，许多研究只能依托标准化造模的方式进行开展，故而本文试图对体内椎间盘模型以及体外椎间盘组织细胞培养模型两大方面综述当前 IDD 的造模进展，为科研人员从研究目的出发选择合适的造模方法提供一定理论依据。

Abstract:

Intervertebral disc degeneration (IDD) is a key pathological process in degenerative spinal diseases, and with the aging ofthe population in society, intervertebral disc-related pathologies have become an important problem that needs to be solved urgently.Cur-rently, there are still some limitations in the study of human intervertebral disc degeneration, and there is no animal model that can compre-hensively simulate the pathological conditions and complex mechanisms of IDD, and many researches can only rely on standardized model-ling.Therefore, this paper attempts to review the current progress of intervertebral disc degeneration modelling from the level of in vivo discmodelling to the level of in vitro intervertebral disc tissue and cell culturing, and to provide a reference for researchers to select the appro-priate model for the purpose of their research.