生物探针辅助诊断假体周围感染的研究进展△

Research progress of biological probe in diagnosis of periprosthetic joint infection

摘要:

假体周围关节感染（periprosthetic joint infection, PJI）是关节置换术后的严重并发症，一旦发生往往宣告了关节置换术的失败。早期的诊断与干预有助于改善患者预后，然而目前仍缺少准确高效的早期诊断手段。病原微生物在 PJI 的发生发展中发挥了重要作用，因此，当怀疑 PJI 发生时，对病原微生物的检测十分重要。近年来，生物探针因其检测迅速、特异性高等优点显示出巨大的应用潜力。本文对关节置换术后 PJI 的诊断进行文献分析，并探讨目前生物探针在病原微生物检测中的应用，为其在 PJI 早期诊断中的应用提供了可能。

Abstract:

Periprosthetic joint infection (PJI) constitutes a severe complication subsequent to joint replacement surgery and represents one of the significant causes of joint replacement failure. Early diagnosis and intervention can enhance patient prognoses, however, an accurate and efficient early diagnostic approach is still lacking. Pathogenic microorganisms play a crucial role in the genesis and development of PJI. Thus, when PJI is suspected, the detection of pathogenic microorganisms is of great significance. In recent years, bioprobes have demonstrated considerable potential for application due to their rapid detection and high specificity. This article conducts a literature review on the diagnosis of PJI after joint replacement surgery and discusses the current application of bioprobes in pathogen detection, offering a possibility for their application in the early diagnosis of PJI.