Abstract:[Objective] To introduce the surgical technique and preliminary clinical outcomes of unilateral bone cement multi-point anchoring percutaneous kyphoplasty (A-PKP) for stage I and II Kümmell's disease (KD). [Methods] A total of 31 patients received abovesaid A-PKA by transverse process-pedicle approach (TPA) for stage I and II KD. Following successful height restoration of the fractured vertebra by balloon expansion, two curved-tip Kirschner wires were prepared and introduced fractured vertebral body. If the intervertebral vacuum cleft (IVC) was close to cephalic or caudal endplate, the "Out-In" puncture was used, a curved Kirschner wire was controlled to puncture the surrounding hardening zone into IVC, while another wire was inserted opposite the endplate. If the IVC was located at the middle of the vertebral body, the "In-Out" puncture was used, a curved-tip Kirschner wire was placed towards upper endplate directly, followed by controlled puncturing from IVC to the surrounding hardened zone, and same procedure was performed with another wire towards the lower endplate from the IVC to the surrounding hardened zone. As results, multiple tiny puncture holes were created on the hardened zone surrounding the IVC. Subsequently, different periods of bone cement were injected sequentially. [Results] All patients had operation performed successfully with the average operation time of (40.6±3.6) min, and the average bone cement injected of (5.2±0.3) mL. Of them, 2 patients had bone cement paravertebral leakage, 3 patients got adjacent vertebral fracture and 1 had bone cement displacement. Compared with those before surgery, the VAS score [(8.1±0.5), (1.7±0.7), P<0.001], the ODI score [(76.8±2.9), (14.6±2.0), P<0.001], anterior vertebral height [(14.9±5.7) mm, (18.7±4.5) mm, P=0.006], posterior vertebral height [(22.4±4.8) mm, (25.0±4.1) mm, P=0.023) and vertebral wedge angle [(15.4±5.1)°, (12.4±3.9)°, P=0.011] were significantly improved at the last follow-up. [Conclusion] The A-PKP for the treatment of stage I and II KD is simple and feasible, with satisfactory clinical consequence and few complications.