Abstract:[Objective] To introduce the surgical technique and preliminary clinical outcome of unilateral biportal endoscopic lumbar interbody fusion (UBE LIF) in the treatment of degenerative scoliosis complicated with spinal stenosis. [Methods] A patient received abovesaid surgical treatment for degenerative scoliosis complicated with spinal stenosis. According to the preoperative clinical menifestation and imaging data, the surgicall segments was determined. The surgical approach and body surface anatomical marks was identified by C-arm fluoroscopy, guide pins were placed under fluoroscopy. Working portals were made over the guide pins, and endoscope and surgical instruments were placed through the upper and lower channels, respectively, to expose and remove the lower edge of the upper vertebral lamina, the tip of upper facet and inner edge of the facet of the lower vertebra. Subsequently, the hypertrophic ligamentum flavum was removed, the outlet root and walking root were exposed, the adhesive tissue was separated, the intervertebral disc was removed. After the intervertebral space was treated, and fusion cage with bone autograft was placed into the space. The other segments were treated in the same manner. After all segments were treated, pedicle screws were inserted along the guide wire, and then fixed with the connecting rods. [Results] The patient successfully completed the operation with operation time of 280 min, the intraoperative blood loss of 180 mL. The patient had incision healed well, got out of bed 3 days after surgery, and followed up for 6 months. The VAS score significantly improved from 5 (low back pain) and 6 (leg pain) preoperatively to 1 at the last follow-up, additionally, the ODI improved from 51.1 to 13.3, and JOA score was from 13 to 23 correspondingly. The patient had no symptoms recurred until the last follow-up. [Conclusion] The UBE-LIF is a minimally invasive technique, and does significantly improve the clinical symptoms of degenerative scoliosis complicated with spinal stenosis, correct scoliosis, restore spinal stability, and promote rapid recovery after surgery