Abstract:[Objective] To investigate the clinical outcome of the integrated rehabilitation based on fast track surgery (FTS) after anterior cruciate ligament reconstruction (ACLR). [Methods] A total of 85 patients who were undergoing ACLR were included in this study and divided into two groups by random number table method. Of them, 43 patients received integrated rehabilitation under the concept of FTS (the intervention group), while other 42 patients were given conventional rehabilitation and nursing care (the routine group). The clinical data were compared between the two groups. [Results] The VAS and HSS scores, as well as knee range of motion and 8 dimensions of SF-36 score were significantly improved in both groups 8 weeks postoperatively compared with those before intervention (P<0.05). There was no statistical significance in the above indexes between the two groups before intervention (P>0.05), however, the intervention group proved significantly superior to the conventional group in terms of VAS score [(4.0±0.5) vs (5.0±0.5), P<0.001], Lysholm score [(68.7±9.3) vs (57.9±6.4), P<0.001], knee range of motion (ROM) [(59.2±8.4)° vs (51.9±6.9)°, P<0.001] and SF-36 score for quality of life in 8 dimensions 8 weeks after intervention. The intervention group was also sigificantly better than the conventional group in term of satisfaction to nursing care at the last follow-up (P<0.05). [Conclusion] The rehabilitation integration intervention based on fast track surgery does promote the rapid recovery after anterior cruciate ligament reconstruction.