Abstract: [Objective] To explore the factors related to poor incision healing after spinal tuberculosis surgery in Xizang region. [Meth ods] From January 2017 to December 2023, 104 patients who received surgical treatment for spinal tuberculosis were included in this study, and the incidence of postoperative poor incision healing was observed. Univariate comparison and multiple logistic regression analysis were used to explore the related factors of poor wound healing. [Results] Among 104 patients who underwent surgical treatment for spinal tuberculosis, 34 patients showed poor wound healing after surgery, accounted for 32.7% (34/104). The poor incision healing group proved significantly greater than the normal healing group in terms of the proportion of irregular anti-tuberculosis treatment [irregular/normal, (21/3) vs (45/25), P＜0.001], the proportion of preoperative hypoproteinemia [yes/no, (26/8) vs (31/29), P=0.002], and the proportion of anemia [yes/no, (22/12) vs (26/44), P=0.008], white blood cells [(8.5±2.5) ×109 /L vs (5.8±2.1) ×109 /L, P＜0.001], CRP [(60.6±39.9) mg/L vs (29.1±29.4) mg/L, P＜0.001], ESR [(39.9±20.3) mm/h vs (22.4±12.0) mm/h, P＜0.001] and the ratio of anterior surgical approach [(anterior/ posterior, (19/15) vs (22/48), P=0.031]. As results of multi-factor logistic regression analysis, the hypoalbuminemia (OR=7.658, P＜0.05), irregular anti-tuberculosis therapy (OR=4.736, P＜0.05), increased white blood cell count (OR=1.560, P＜0.05), accelerated ESR (OR=1.149, P＜0.05), and high CRP level (OR=1.019, P＜0.05) were the independent risk factor for poor incision healing after spinal tuberculosis surgery. [Conclusion] Preoperative irregular anti-tuberculosis therapy, hypoalbuminemia, increased white blood cell count, accelerated erythrocyte sedimentation rate and high C-reactive protein level are independent risk factors for poor wound healing after surgery for tuberculosis.