胰岛素样生长因子-1在椎间盘退变中的作用△

Role of insulin-like growth factor 1 in intervertebral disc degeneration

摘要:

腰背痛（low back pain, LBP）是肌肉骨骼系统退行性疾病常见的症状，已成为全世界严重的医学和社会问题，导致患者的生活质量低下并耗费大量的医疗资源。椎间盘退变 （intervertebral disc degeneration, IVDD） 导致 LBP 占腰痛原因的近 40%。目前，IVDD 的具体发病机制尚不完全清楚。胰岛素样生长因子-1（insulin-like growth factor -1, IGF-1）是一种关键的生长促进肽，在软骨细胞的增殖、分化、凋亡以及调节细胞外基质（extracellular matrix, ECM）方面有很重要的作用。研究表明， 在 IVDD 过程中 IGF-1 可以调节多个靶基因并激活不同的途径，参与 ECM 降解、凋亡以及衰老的调节。IGF-1 可能成为 IVDD 一个有前景的新的治疗靶点。本文就 IGF-1 和 IVDD 发展之间的潜在关系进行综述。

Abstract:

Low back pain (LBP) is a common symptom of degenerative diseases of the musculoskeletal system, and has become a serious medical and social problem worldwide, resulting in poor quality of life for patients and consuming a large amount of medical resources. Intervertebral disc degeneration (IVDD) caused LBP accounted for about 40%, while the specific pathogenesis of IVDD is not fully understood at present. Insulin-like growth factor 1 (IGF-1) is a key growth-promoting peptide, which plays a key role in the proliferation, differentiation, apoptosis and regulation of the extracellular matrix (ECM) of chondrocytes. Previous studies have shown that IGF-1 can regulate multiple target genes and activate different pathways during IVDD, and participate in the regulation of ECM degradation, apoptosis and senescence. This paper discusses the potential relationship between IGF-1 and IVDD development, and IGF-1 may be a promising new therapeutic target for the clinical management of IVDD.