Abstract: [Objective] To evaluate the clinical outcome of the nursing intervention based on information-motivation-behavior (IMB) model for posterior lumbar interbody fusion (PLIF). [Methods] A total of 100 patients who were undergoing PLIF for lumbar degenerative diseases in our hospital from May to October 2023 were enrolled into this study and divided into 2 groups by random number table method. Of them, 50 patients received IMB care, while other 50 patient underwent conventional care. The clinical data of the two groups were compared. [Results] There were no significant differences in operation time, intraoperative blood loss, postoperative drainage and total complications between the two groups (P>0.05). However, the IMB group proved significantly superior to the conventional group in terms of postoperative bed rest time [(3.4±0.4) days vs (4.2±0.5) days,P<0.001] and hospital stay [(11.0±2.3) days vs (12.1±3.5) days, P=0.049], as well as VAS score [(4.1±0.7) vs (4.5±0.7), P=0.010; (1.1±0.7) vs (1.5±0.9), P=0.032], ODI score [(51.4±1.9) vs (55.1±1.7), P<0.001; (21.3±2.1) vs (23.5±2.1), P<0.001], compliance score [(54.6±1.7) vs (49.7±3.2), P<0.001; (57.0±2.4) vs (53.9±1.9), P<0.001], HADS-D score [(8.7±1.5) vs (9.4±1.9), P=0.046; (5.9±1.6) vs (6.7±1.5), P=0.020] at discharge and 1 month after surgery, additionally, HADS-A score [(8.2±1.8) vs (9.5±1.7), P<0.001] at discharge. [Conclusion] IMB based nursing intervention can reduce postoperative pain of PLIF, promote the recovery of lumbar function, improve their exercise compliance, reduce the occurrence of anxiety and depression, and shorten the hospital stay.