Abstract:[Objective] To evaluate the clinical outcome of individualized phased rehabilitation for one-stage repair and reconstruction of multi-ligamentous knee injuries (MLKI). [Methods] A retrospective study was performed on 20 patients who admitted into our department for MLKI from January 2016 to December 2023. All of whom received one-stage surgical repair and reconstruction, followed by personalized phased rehabilitation. The clinical data of the patients were evaluated. [Results] All patients were operated on successfully. Among 20 patients, 10 patients were of ACL/PCL/MCL combined injuries, 6 of ACL/PCL/PLC combined injuries, 3 of ACL/MCL combined injuries and 1 of PCL/PLC injuries. Regarding surgical treatment, ACL repair was performed in 1 case, ACL reconstruction in 18, PCL repair in 1, PCL reconstruction in 16, PMC repair in 11, PMC reconstruction in 2, PLC repair in 1 and PLC reconstruction in 6 cases. As time elapsed preoperatively, 1 month after operation and the last follow-up, knee ROM [(76.0±2.6)°, (79.2±2.2)°, (130.0±2.5)°, P<0.001], VAS score [(5.0±0.5), (4.2±0.4), (1.1±0.2), P<0.001], Lysholm score [(38.0±1.8), (42.0±2.3), (87.2±2.9), P<0.001], IKDC scores [(42.2±1.9), (45.3±2.4), (87.4±1.8), P<0.001] and KSS score [(40.0±1.9), (43.3±1.7), (87.0±1.8), P<0.001] were significantly improved. During the followup, none of the patients had revision surgery. [Conclusion] After the onestage repair and reconstruction of MLKI, individualized stage rehabilitation according to the actual situation of patients does effectively improve the consequence and reduce the occurrence of postoperative knee dysfunction.