Abstract:[Objective] To evaluate the effectiveness of adductor canal block (ACB) combined with popliteal plexus block (PPB) in total knee arthroplasty (TKA). [Methods] From January 2022 to January 2023, a total of 100 patients who underwent the primary unilateral TKA under intravenous and inhalant combined general anesthesia for knee osteoarthritis were included in this study, and randomly divided into two groups by random number table method. Of them, 50 patients received PPB combined ACB (the combined group), while the other 50 patients received ACB only (the ACB group). The clinical and analgesic data of the two groups were compared. [Results] There was no significant difference in intraoperative blood loss, operation time and total adverse reactions between the two groups (P>0.05). The combined group proved significantly superior to the ACB group in terms of ambulation time [(22.5±4.4) days vs (28.6±5.7) days, P<0.001] and hospital stay [(7.2±1.1) days vs (8.0±1.3) days, P<0.001]. In addition, the combined group was also significantly superior to the ACB group in knee ROM 1 day and 3 days postoperatively [(88.4±15.8)° vs (67.7±14.5)°, P<0.001; (96.6±17.9)° vs (83.5±15.7)°, P<0.001]. As for analgesia data, the combined group had significantly lower NRS score than the ACB group from 2 hous to 48 hous after surgery (P<0.05), despite of the fact that the difference between the two group became not statistically significant 72 hours after surgery (P>0.05). Furthermore, the combined group was significantly superior to the ACB group regarding to the first time of analgesic pump compressed [(7.4±2.0) hours vs (5.5±1.6) hours, P<0.001], the number of analgesic pump compression times, vasoactive drug use times and number of remedial analgesia (P<0.05). [Conclusion] The use of PPB combined with ACB in TKA does alleviate early postoperative pain symptoms, shorten bed rest and hospital stay, and is conducive to the recovery of knee ROM.