Abstract: [Objective] To evaluate the efficacy of arthroscopic double-loop suture bridge with knotless anchors in the treatment of large and medium-sized rotator cuff tears (RCTs) in the elderly. [Methods] A retrospective study was conducted on 102 elderly patients who underwent arthroscopic repair of large and medium-sized RCTs in our hospitals from March 2021 to December 2023. According to preoperative doctor-patient communication, 52 patients received double-loop suture bridge with knotless anchors, while the other 50 patients underwent the traditional suture bridge with knotted anchors. The perioperative, followup, and imaging data were compared between the two groups. [Results] The knotless group consumed significantly shorter operation time than the knotted group [min, (80.0±11.3) vs (86.2±10.5), P=0.005], but there were no statistically significant differences between the two groups in terms of total incision length, intraoperative blood loss, number of anchors used, time to return active movement, incision healing grade, and hospital stay (P>0.05). The average follow-up time was of (20.0 ± 3.6) months, and the knotless group achieved full weight-bearing activity significantly earlier than the knotted group [weeks, (17.4±2.0) vs (18.5±2.4), P=0.013]. The VAS, UCLA, Constant-Murley, and ASES scores, as well as forward elevation, abduction elevation, and internal-external rotation range of motions (ROMs) in both groups improved significantly over time (P<0.05). The knotless group proved significantly superior to the knotted group in terms of UCLA [points, (25.6±2.8) vs (23.8±3.0), P=0.002], Constant-Murley [points, (83.6± 4.2) vs (81.0±4.7), P=0.004], and ASES scores [points, (78.5±4.5) vs (75.6±4.8), P=0.002] 6 months postoperatively, whereas which became not statistically significant between the two groups at the last follow-up (P>0.05). As for imaging, the knotless group were also significantly better than the knotted group regarding to acromiohumeral distance (AHD) [mm, (12.6±1.5) vs (11.9±1.6), P=0.025] and acromion index (AI) [(0.68±0.06) vs (0.71±0.07), P=0.022] 6 months postoperatively, but no statistically significant differences between the two groups at the last followup (P>0.05). In addition, there was no statistically significant difference in rotator cuff integrity between the two groups (P>0.05). [Conclusion] The knotless double-loop suture bridge does shorten the operation time and full weight-bearing activity time, and has obvious advantages in mid-term shoulder joint function and AHD and AI improvement over the knotted counterpart.