铈和铈基材料在骨科临床应用的进展

Progress in clinical application of cerium and cerium-based materials in orthopedics

摘要:

铈（cerium, Ce）是地壳中丰度最高的稀土元素。在纳米尺度上，Ce³⁺与Ce⁴⁺之间的可逆转换伴随着其晶格结构中氧空位的产生和消除，从而产生双重氧化还原特性，有助于清除生物体中多余的氧自由基。过多的活性氧（reactive oxygen species, ROS）会诱导骨重塑微环境的紊乱，并导致病理性骨骼疾病的发生，如类风湿性关节炎、骨质疏松症、骨关节炎、骨折延迟愈合。Ce因具有抗氧化、抗炎、成骨和成血管等多种生物学活性而被广泛应用于骨科疾病的治疗。本文就Ce的生物学活性以及Ce基材料在骨科临床应用中的进展进行综述，旨在为开发针对不同骨科疾病的Ce基材料提供新思路，并强调了这一领域未来发展的挑战。

Abstract:

Cerium (Ce) is recognized as the most abundant rare element within the Earth's crust. In the nanoscale, the reversible inter-conversion between Ce³⁺ and Ce⁴⁺ is associated with the generation and elimination of oxygen vacancies in its lattice structure, which results in dual redox properties that facilitate the scavenging of excess reactive oxygen species (ROS) from living organisms. An overabundance of ROS can disrupt the microenvironment of bone remodeling, potentially leading to the development of various pathological bone conditions, including rheumatoid arthritis, osteoporosis, osteoarthritis, and delayed fracture healing. Due to its diverse biological activities, such as anti-oxidative, anti-inflammatory, osteogenic, and angiogenic properties, Ce has been extensively utilized in the treatment of orthopedic diseases. This article review the biological activities of Ce and the advancements in Ce-based materials in the clinical orthopedic practise to provide innovative perspectives for the development of Ce-based materials targeting various orthopedic diseases while also addressing the challenges that lie ahead in this field.