Abstract:[Objective] To explore the clinical efficacy of suture anchor on the talus for repairing deep deltoid ligament rupture combined with ankle fractures. [Methods] A retrospective study was conducted on 32 patients who received the above surgical treatment from January 2022 to February 2024. The clinical and imaging data were evaluated. [Results] All the patients had the operations performed successfully, with the average operation time of (98.5±21.4) min, and the average intraoperative blood loss of (43.1±10.3) mL, whereas without intraoperative or postoperative complications. All patients were followed up for a mean of (15.3±2.6) months. Compared with those preoperatively, the VAS [points, (7.6±1.2), (3.2±0.4), (1.0±0.3), P<0.001], AOFAS [points, (42.3±3.6), (83.4±7.7), (92.3±3.4), P<0.001], and ankle dorsiflexion-plantar flexion ROM [°, (22.3±3.1), (41.2±3.6), (52.3±2.8), P<0.001] were significantly improved 3 months postoperatively and at the last follow-up. As for imaging, the medial clear space (MCS) [mm, (5.2±0.4), (2.6±0.3), (2.4±0.2), P<0.001], tibiofibular clear space (TFCS) [mm, (8.1±0.3), (1.7±0.5), (1.7±0.6), P<0.001], and talocrural angle (TCA) [°, (87.5±1.2), (83.2±1.6), (83.5±1.7), P<0.001] were significantly improved 3 months after operation and at the last follow-up compared with those before operation. [Conclusion] The suture anchor on the talus for repairing deep deltoid ligament rupture combined with ankle fractures achieves satisfactory clinical consequence with good recovery of joint function.