Abstract:[Objective] To investigate the analgesic effect of ultrasound-guided anterior iliopsoas space block on pain relief and functional recovery after hip arthroplasty (HA). [Methods] A total of 60 patients who were undergoing HA in the Affiliated Hospital of Jiangsu University from June 2023 to May 2024 were enrolled into this study, and randomly divided into the block group and the non-block group, with 30 cases in each group. Both groups received subarachnoid anesthesia, additionally, the block group received anterior iliopsoas space block before the operation, while the non-block group received no block. Both groups received patient-controlled intravenous analgesia after the operation. The data regarding postoperative analgesia were compared between the two groups. [Results] All patients in both groups had HA performed successfully. The block group proved significantly superior to the nonblock group in terms of ambulation time [(4.2±0.9) days vs (6.0±1.2) days, P<0.001], total sufentanil consumption after surgery [(19.3±3.1) μg vs (22.7±5.6) μg, P=0.007], rescue analgesia rate [4 (13.3%) vs 18 (60.0%), P<0.001], and total adverse reaction rate [7 (23.3%) vs 24 (80.0%), P<0.001], although there were no statistically significant differences in the incidence of postoperative urinary retention, respiratory depression, and delirium between the two groups (P> 0.05). In addition, the block group was significantly better than the non-block group in the pain VAS scores at 6 hours, 1, 3, and 7 days after surgery [(1.8±1.0) score vs (3.5±1.5) score, P<0.001; (2.4±0.5) score vs (3.0±0.9) score, P=0.005; (1.9±0.6) score vs (2.3±0.6) score, P= 0.017; (0.9±0.6) score vs (1.3±0.6) score, P=0.012], and the 2-minute walking distance at 24 and 48 hours after surgery [(44.2±12.0) m vs (36.2±10.5) m, P=0.020; (170.4±9.9) m vs (120.9±18.2) m, P<0.001]. [Conclusion] The ultrasound-guided anterior iliopsoas space block does effectively alleviate postoperative pain after hip arthroplasty, promote functional recovery, and does not increase adverse reactions.