Erastin诱导细胞铁死亡在肿瘤治疗中的研究进展

Role of erastin in ferroptosis and its application in cancer treatment

摘要:

铁死亡是一种铁依赖性的新型细胞程序性死亡形式，其特征是细胞内致死水平活性氧簇 (reactive oxygen species, ROS)以及脂质过氧化物(lipid peroxidation)累积。Erastin 是一类经典的铁死亡诱导剂，能够作用于各种分子结构诱导铁死亡的发生，同时在抗肿瘤的应用方面展现广阔的前景。本篇文章对 Erastin 诱发铁死亡的机制及其抗肿瘤的临床应用情况进行综述。

Abstract:

Ferroptosis is an iron-dependent and newly regulated cell death, which characteristics is excessive accumulation of reactive oxygen species (ROS) and lipid peroxidation. Erastin, a classic ferroptosis inducer, can mediates ferroptosis through a variety of molecules. Meanwhile, erastin shows a promise perspective in anti-tumor application. This article reviews the mechanism of erastin inducing ferropto- sis as well as its anti-tumor clinical application.