褪黑素在椎间盘退变中的研究进展

Research progress of melatonin in intervertebral disc degeneration

摘要:

椎间盘退变是下腰痛的主要因素之一，随着老年社会的到来，其发病率逐年升高，由于椎间盘退变 (intervertebral disc degeneration, IDD)致病因素众多，其发病机制尚不清楚，目前仍无有效治疗药物。褪黑素(melatonin, MT)作为松果体分泌的一种神经内分泌激素，因其卓越的抗氧化应激、抗炎及抗细胞凋亡等作用在肿瘤、年龄相关性退行性疾病等邻域有着广泛的研究，本文就 MT 延缓 IDD 机制研究做一综述，为后续相关研究提供参考。

Abstract:

Intervertebral disc degeneration (IDD) is one of the main reasons of low back pain. With the advent of the elderly society, its incidence is increasing year by year. Due to numerous pathogenic factors involving intervertebral disc degeneration, the pathogenesis is still unclear, and there is no effective drug for IDD. As a kind of neuroendocrine hormone secreted by pineal gland, melatonin (MT) has been widely studied in tumor, age-related degenerative diseases and so on because of its excellent anti-oxidation stress, anti-inflammatory and anti-apoptosis effects. This paper reviews the mechanism of MT to delay IDD and provides a reference for future research.