Abstract:[Objective] To explore the clinical efficacy, safety and advantages of proximal fibular osteotomy (PFO) for treatment of me- dial knee osteoarthritis (KOA) . [Methods] A retrospective study was conducted on a total of 60 patients who underwent PFO for medial KOA in our hospital from February 2020 to February 2021. The VAS, HSS, KSS clinical and functional scores were compared among differ- ent time points. [Results] In terms of adverse events, intermuscular vein thrombosis was seen in 2 patients (3.33%) , limited motion of hal- lux dorsal extension was noted in 1 patient (1.67%) , hallux brevis contracture was found in 2 patients (3.33%) , and palsy of common pero- neal nerve was in only 1 patient (1.67%) . The VAS score decreased significantly (P<0.05) , whereas the HSS score, as well as KSS clinical and functional scores significantly increased over time (P<0.05) . At the last follow-up, 43 patients (71.67%) had no medial knee pain total- ly, 15 patients (25.00%) got medial knee pain significantly relieved, 1 patient (1.67%) had pain location changed, and 1 patient (1.67%) re- mained pain unchanged. [Conclusion] PFO is a safe, minimally invasive and cost-efficient surgical treatment, does obviously relieve the pain and improve the function for medial KOA.