microRNAs在脊髓损伤中的研究进展

Research progress of microRNAs in spinal cord injury

摘要:

脊髓损伤 (spinal cord injury, SCI) 的继发性病变如氧化应激、凋亡等会进一步加重神经功能损害。microRNAs (miRNAs)是一类新型的小非编码 RNAs，其通过沉默翻译或干扰靶 mRNAs 的表达调控蛋白质的产生和细胞功能。SCI 改变了氧化应激、炎症和凋亡等许多继发性损伤相关的 miRNAs 的表达。本综述旨在阐明 miRNAs 在脊髓损伤后凋亡及氧化应激中的最新研究进展，指导 miRNAs 在脊髓损伤中的进一步研究。

Abstract:

Secondary lesions of spinal cord injury (SCI) , such as oxidative stress and apoptosis, further aggravate the neurological im- pairment. The microRNAs (miRNAs) are a novel class of small non-coding RNAs that regulate protein production and cell function by si- lencing translation or interfering with the expression of target mRNAs. SCI alters the expression of miRNAs associated with many secondary injuries such as oxidative stress, inflammation and apoptosis. This review aims to clarify the latest research progress of miRNAs in apopto- sis and oxidative stress secondary to spinal cord injury, and to provide a reference for further research of miRNAs in spinal cord injury.