Abstract:[Objective] To explore the clinical outcomes of locking plate for internal fixation of Seinsheimer type V femoral subtrochan- teric fractures. [Methods] From September 2014 to January 2019, 16 patients underwent open reduction and internal fixation with locking plate for Seinsheimer type V femoral subtrochanteric fractures. The perioperative status and follow-up results of the patients were recorded. [Results] All the 16 patients had operation performed successfully with incision length of (12.50±1.45) cm, operation time of (133.75± 18.21) min, and blood loss intraoperatively of (493.75±83.42) ml, whereas a patient got incision fat liquefaction after operation. The postop- erative follow-up period lasted for (22.52±5.04) months on average, while clinical fracture healing achieved in (7.88±1.15) months on aver- age. At the latest follow-up, the patients had VAS score of (0.50±0.63) , hip extension-flexion range of motion (ROM) of (135.88±6.30)°, and Harris score of (88.19±6.28) on average. The clinical outcome was marked as excellent in 10 cases, good in 5 cases, fair in 1 case, with an excellent and good rate of 93.75%. [Conclusion] The Seinsheimer type V femoral subtrochanteric fractures is difficult for reduction and fixation, however, locking plating is a safe and effective surgical method with good fracture healings and satisfactory clinical results.