Abstract:[Objective] To explore the clinical efficacy of unilateral biportal endoscopy for far-migrated lumbar intervertebral disc her- niation. [Methods] From April 2020 to December 2020, 19 patients underwent unilateral biportal endoscopy for far-migrated lumbar inter- vertebral disc herniation in our department. The documents of perioperative period, follow-up and radiographic results were summarized. [Results] All patients had operation completed successfully without serious complications, while with operation time of (75.37±13.62) min, blood loss of (61.84±20.45) ml, and times of fluoroscopy of (2.84±0.83) . The VAS score for lower back pain and leg pain continued to de- crease significantly after the operation (P<0.05) , and the pain almost disappeared by 30 days after the operation. The modified ODI score decreased significantly, while the JOA score increased significantly over time (P<0.05) . Based on Modified Macnab criterion, the clinical outcomes were marked as excellent in 16 cases, good in 2 cases and fair in 1 case with excellent and good rate of 94.74%. At the latest fol- low-up, MRI showed far-migrated lumbar intervertebral discs were successfully removed without recrudescence. [Conclusion] Unilateral biportal endoscopy is an effective method for treatment of far-migrated lumbar intervertebral disc herniation.