Abstract:[Objective] To evaluate the clinical efficacy of ankle arthroscopic debridement combined with anatomical reconstruction of the lateral collateral ligament by autograft peroneus brevis tendon for chronic lateral ankle instability. [Methods] From October 2016 to Oc- tober 2018, a total of 18 patients received ankle arthroscopic debridement, followed by anatomical reconstruction of the anterior talofibular ligament (ATFL) and calcaneofibular ligament (CFL) with ipsilateral part of peroneus breus tendon for chronic lateral ankle instability. The clinical outcomes were assessed by using AOFAS and VAS scores, as well as radiographic examination. [Results] All the 18 patients were successfully operated on without serious complications, while with operation time of (71.56 ± 6.06) min and intraoperative blood loss of (46.50±5.38) ml. Over time during follow up lasted for (19.89±1.68) months, the AOFAS score significantly increased (P<0.05) , whereas the VAS score significantly decreased (P<0.05) . As findings on postoperative X-rays, ankle alignment was normal with anchor and bone tunnel in proper position. In addition, the MRI revealed that the reconstructed ATFL and CFL were in normal shape with proper tension. [Conclusion] Ankle arthroscopic debridement combined with anatomical reconstruction of the lateral collateral ligament by using partial peroneus brevis tendon for chronic lateral ankle instability does achieve satisfactory clinical results, with the advantages of less trauma, sim- ple operation and fewer complications.