Abstract:[Objective] To evaluate the clinical outcomes of total hip arthroplasty (THA) in the treatment of failed intramedullary fixa- tion for femoral intertrochanteric fractures. [Methods] A retrospective study was conducted on 21 patients (21 hips) who underwent THA in our department for failed proximal femoral nail anti-rotation (PFNA) fixation of femoral intertrochanteric fractures from June 2014 to De- cember 2019. The perioperative and follow-up documents were summarized. [Results] All the patients were operated on smoothly without serious complications, such as vascular and nerve damage during the operation, whereas with operation time of (153.53±12.45) min, intraop- erative blood loss of (400.52±45.97) ml, blood transfusion of (250.65±66.82) ml, and well incision healing. As time went during the followup period lasted for (20.70±6.90) months on average, both the Harris and SF-12 scores increased significantly (P<0.05) . No serious late complications, such as periprosthetic fracture, periprosthetic joint infection, as well as aseptic loosening, periprosthetic osteolysis and het- erotopic ossification seen on images were noticed in anyone of them to the latest follow up. [Conclusion] THA is effective treatment to save joint function and improve the quality of life for failed PFNA fixation of intertrochanteric fractures.