椎间盘退变模型建立的研究进展△

Research progress in the establishment of intervertebral disc degeneration model

摘要:

腰痛是全球性健康问题，与椎间盘退变有关，但机制不明。目前可以通过建立动物模型，来探索椎间盘退变的机制以及新的治疗靶点。椎间盘退变动物模型大致可分为 4 种类型。本文主要综述了椎间盘退变模型的不同制备方法，比较各种模型优缺点及适合的研究领域。

Abstract:

Low back pain is a global health problem, which is related to intervertebral disc degeneration (IDD) , but the mechanism is unknown. At present, it is possible to explore the pathogenesis of intervertebral disc degeneration and new therapeutic targets through the establishment of animal models. Animal models of intervertebral disc degeneration can be roughly divided into 4 types. This article mainly reviews the different methods to create intervertebral disc degeneration models, and compares the advantages and disadvantages of various models to meet suitable research fields.