自噬在骨关节炎发病和治疗中的作用研究现状△

Current research on the role of autophagy in the pathogenesis and treatment of osteoarthritis

摘要:

自噬是机体内高度保守的细胞降解代谢胞内物质的过程，其功能是维持细胞内环境稳定，保护和维持细胞生存。自噬功能障碍与衰老和包括骨关节炎 (osteoarthritis, OA) 在内的多种退行性疾病有关。因此，维持细胞自噬稳态和功能十分重要。OA 是一种引起关节软骨不可逆的进行性破坏的退行性疾病，但目前尚无有效的方法来延缓 OA 的进展。近 10 年来，越来越多证据表明自噬在 OA 发病中发挥重要作用，调控自噬活性可以阻止关节软骨退变。鉴于自噬在 OA 中的重要作用，本文就自噬与 OA 的关系、调控 OA 进展的关键自噬分子和相关信号通路，以及靶向自噬通路治疗 OA 的药物作一综述。

Abstract:

Autophagy is a highly conserved catabolic process induced under cellular stress, which prevents cell damage and promotes survival. Autophagy dysfunction is associated with aging and a variety of degenerative diseases, including osteoarthritis (OA). Therefore, it is very important to maintain autophagy homeostasis and function. OA is a degenerative disease that causes irreversible and progressive de- struction of articular cartilage. However, there is no effective method to delay the progression of OA. In the past decade, more and more evi- dence has shown that autophagy plays important roles in the pathogenesis of OA, and regulating autophagy activity can prevent articular car- tilage degeneration. In view of the important role of autophagy in OA, this paper reviews the relationship between autophagy and OA, the key autophagy molecules and related signaling pathways that regulate the progression of OA, as well as related drugs targeting autophagy pathways for the treatment of OA.