Abstract:[Objective] To compare the clinical efficacy of arthroscopic anchor suture bridge technique and open reduction and inter- nal fixation in the treatment of avulsion fracture of the humeral greater tuberosity. [Methods] The databases, including PubMed, Cochrane, Embase, CNKI, Wanfang and VIP were searched by using computer to select the literatures on the treatment of avulsion fracture of humeral greater tuberosity by arthroscopic and open methods from the establishment of the database to May 2021. After the quality of the included literatures was evaluated, the data were extracted and analyzed by RevMan5.3 software. [Results] A total of 6 articles were included, involv- ing 390 patients. Of them, 188 patients received arthroscopic anchor suture bridge technique, whereas 202 patients underwent open reduc- tion and internal fixation (ORIF) . As results of meta-analysis, the arthroscopic group proved significantly superior the the ORIF group in term of shoulder flexion range of motion, abduction range of motion, 90° internal rotation,VAS score, ASES score and complication rate (P< 0.05) . However, the arthroscopic group consumed significantly longer operation time than the ORIF group (P<0.05) . There was no signifi- cant difference between the two groups in intraoperative bleeding, shoulder extension range of motion, 0° external rotation and 90° external rotation (P>0.05) . [Conclusion] Arthroscopic anchor suture bridge technique does alleviate postoperative pain and promote the recovery of shoulder function, is helpful to reduce the incidence of complications, whereas has disadvantage of longer operation time which lead to po- tential risk accordingly.