Abstract:[Objective] To evaluate the effect of additional ultrasound-guided erector spinae plane block in general anesthesia for lum- bar fusion. [Methods] A total of 60 patients who received lumbar fusion under general anesthesia were included in this study. According to the results of doctor- patient communication, 30 patients had erector spine block added before surgery, while the remaining 30 patients were treated with conventional general anesthesia without block anesthesia. The clinical outcomes of the two groups were compared. [Results] All patients in both groups were successfully operated on. The mean artery pressure (MAP) and heart rate (HR) remained stable in the block group at each time point (P>0.05) , whereas which significantly increased at skin cutting and disc resection in the routine group (P<0.05) , with statistically significant differences between them (P<0.05) . The block group proved significantly superior to the routine group in terms of amount of sufentanil used and stay time in recovery room (P<0.05) . In addition, the block group was also superior to the routine group in the qOR-15 score 24 h after surgery (P<0.05) , despite that became not significant between the two groups 48 h after sur- gery (P>0.05) . Furthermore, the block group proved significantly superior to the routine group in the resting and active NRS scores at 6 h and 12 h after surgery, whereas which became not statistically significant between them at 24 h after surgery (P>0.05) . Moreover, the block group had significantly lower dosage of sufentanil consumed than the routine group 48 h after operation (P<0.05) , with significantly lower incidence of adverse reactions (P<0.05) . [Conclusion] The additional ultrasound-guided erector spinae plane block does improve the anal- gesic effect and reduce the adverse reactions in general anesthesia for lumbar fusion surgery in this study.