Abstract:[Objective] To explore the clinical outcomes of internal fixation and scapholunate interosseous ligament (SLIL) repair for distal radius fractures accompanied with scapholunate dissociation (SLD) . [Methods] A retrospective study was performed on 14 patients who underwent internal fixation and SLIL repair for acute distal radius fractures accompanied with SLD in our hospitals from June 2014 to December 2019. The clinical and radiographic consequences were evaluated. [Results] During operation partial rupture of SLIL was found in 9 patients, while complete SLIL tear was noted in 5 patients. All the patients had surgical procedures performed smoothly without serious complications, such as neurovascular injuries. As time went during the follow up lasted for (19.12±5.84) months on an average, the VAS score significantly decreased (P<0.05) , whereas the Mayo wrist score significantly increased (P<0.05) . At the latest follow up, there were no significant differences in terms of range of motions (ROMs) in dorsal extension, pronation and supination, as well as grip strength be- tween the affected and unaffected sides (P>0.05) , despite that the affected side had significantly less palmar flexion than the unaffected side (P<0.05) . Radiographically, the scapholunate space and angle significantly improved postoperatively compared with those preopera- tively to the normal ranges (P<0.05) , associated with significant improvement in radial inclination and volar tilt (P<0.05) , regardless of un- changed ulnar variation (P>0.05) . All the patients got fracture healed with SLD corrected on imaging at the latest follow up. [Conclusion] The internal fixation and SLIL repair do achieve satisfactory clinical outcomes for acute distal radius fractures accompanied with SLD.