Abstract:[Objective] To evaluate the clinical efficacy of transcranial direct current stimulation (tDCS) combined with core exercise for non-specific low back pain (NLBP) . [Methods] From June 2017 to June 2020, 64 patients with NLBP were enrolled in this study and random- ly divided into two groups. Among them, 32 patients were treated with transcranial electrical stimulation combined with core exercise (com- bined group) , while the remaining 32 patients were treated with conventional physical therapy (conventional group). The early and follow-up consequences were compared between the two groups. [Results] The treatment period of the combined group was shorter than that of the conven- tional group, but the difference was not statistically significant (P>0.05) . There were no adverse reactions during treatment without a significant difference in treatment compliance between the two groups (P>0.05) . However, the treatment cost and patient satisfaction in the combined group were significantly higher than those in the conventional group (P<0.05) . All patients were followed up for an average of (9.34±4.12) months. The combined group proved significantly superior to the conventional group in the time to recover previous work and recurrence rate (P< 0.05) . The combined group got significant decline in terms of VAS and ODI scores, as well as core instability parameters, such as OSI, APSI and MLSI (P<0.05) , whereas significant increment of JOA score after treatment compared with those before treatment (P<0.05) . By contrast, the con- ventional group also got significant improvements in terms of VAS, ODI and JOA scores after treatment compared with those before treatment (P< 0.05) , however, remained unchanged in the OSI, APSI and MLSI (P>0.05) . Although there were no significant differences in the abovesaid items between the two groups before treatment (P<0.05) , the combined group proved significantly superior to the conventional group in all above- mentioned parameters at the end of treatment, 6 months after treatment and the last follow-up (P<0.05) . [Conclusion] The transcranial direct current stimulation combined with core exercise does effectively relieve pain, improve function and postural control ability for NLBP.