Abstract:[Objective] To evaluate the clinical outcomes of bone cement filling bone defect of the first metatarsal secondary to tophus erosion. [Methods] A retrospective study was done on 32 patients who received bone cement filling combined with Kirschner wire place- ment for the bone defect of the first metatarsal secondary to tophus debridement in our hospital from January 2017 to December 2019. The metatarsophalangeal range of motion (ROM) , VAS score, hallux valgus angle measured on radiographs and blood uric acid were compared before and after operation. [Results] All patients were successfully operated on without complications, and were followed up for 12~18 months, with a mean of (15.92±2.41) months. At the last follow-up, the ROM, VAS and AOFAS scores significantly improved compared those preoperatively (P<0.05) . As findings of X-ray films, the bone cement was in place firmly without separation and displacement, while with proper preservation of metatarsophalangeal space and unchanged hallux valgus angle (P<0.05) . However, the blood uric acid had no significant change before and after operation (P<0.05) . [Conclusion] Bone cement filling bone defect of the first metatarsal secondary to to- phi removed does preserve the metatarsophalangeal joint function to the maximum extent and improve the range of motion, which is an effec- tive treatment of the first metatarsophalangeal tophi in the early stage.