Abstract:[Objective] To explore the clinical outcomes and occupational protection of surgical treatment for thoracolumbar tuberculo- sis complicated with AIDS. [Methods] From November 2011 to May 2019, 21 patients underwent debridement and instrumented fusion through posterior approach for thoracolumbar tuberculosis complicated with AIDS in our department. Clinical results and documents regard- ing to occupational exposure and protection of the medical staff were analyzed. [Results] All patients were operated on successfully without serious complications. At the latest follow-up lasted for (16.97±4.42) months, both VAS score and ASIA neurological function scales signifi- cantly improved compared with those preoperatively (P<0.05) . In term of radiographic assessment, all the patients got bone fusion, without lesion recurrence, internal fixation loosening or fracture by the time of the latest follow-up. Regarding occupational exposure, a total of 5 ex- posures occurred during operation, mainly in the process of surgical instrument transfer and surgical suture, involving needle puncture and eye spatter. All occupationally exposed medical workers were treated immediately without the infection detected 12 months later. [Conclusion] The surgical treatment is still effective approach to thoracolumbar tuberculosis complicated with AIDS, and occupational protection, especially for the hands and eyes, should be highly lightened during the operation.