Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of unilateral biportal endoscopy (UBE) for double-segment lumbar spinal stenosis. [Methods] A total of 8 patients underwent UBE for double-segment lumbar spinal stenosis. The horizontal line of the three incisions passed through the lower edge of the pedicle of the upper vertebral body, the midpoint of the pedicle of the middle vertebral body, and the upper edge of the pedicle of the lower vertebral body, respectively. The intersection point between the line and the horizontal line of the inner edge of the left vertebral pedicle was the incision point. The observation channel and operation chan- nel were established successively to keep the lavage fluid flowing smoothly. The spinal canal was decompressed by using bur, osteotome, rongeur and other instruments, and then the discectomy was performed. On the second day after surgery, the patient got out of bed with a brace for 2 months. The VAS score, Oswestry disability index and modified Macnab criteria were used to evaluate the clinical efficacy. [Results] All patients had operation completed successfully with operation time of (192.52±14.14) min, whereas intraoperative dural sac tear happened in only 1 case. As time went during the follow-up lasted for (10.62±6.36) months (range, 6~15 months) , the VAS score and ODI score decreased significantly (P<0.05) , in other word, the symptom relief became more obvious. At latest follow-up, the clinical outcomes were marked as excellent in 5 cases, good in 2 cases and fair in 1 case, with an excellent and good rate of 87.5%. [Conclusion] The unilat- eral biportal endoscopy is an effective method for the treatment of double-segment lumbar spinal stenosis.