Abstract:[Objective] To evaluate the clinical efficacy of head-neck fenestration bone autografting through direct anterior approach (DAA) for pericollapse-stage femoral head necrosis. [Methods] A retrospective study was conducted on 32 patients (37 hips) who under- went head-neck fenestration bone autografting through DAA for pericollapse-stage femoral head necrosis from September 2015 to March 2018. The clinical and imaging results were observed. [Results] All patients were successfully operated on without neurovascular injury and other serious complications. During follow-up period lasted for (35.23±10.35) months, 5 patients (5 hips) who had clinical symptoms worsen, including 2 hips turned to total hip arthroplasty (THA) , were judged as hip preservation failure, accounting for 13.51%, while the remaining 27 patients (32 hips) who got continuous improvement in clinical symptoms were marked as successful hip preservation, account- ing for 86.49%. The VAS score for hip pain significantly decreased (P<0.05) , while Harris score, hip extension-flexion, internal-external rotation range of motions (ROMs) significantly increased at the latest follow up compared with those preoperatively (P<0.05) . Radiographi- cally, there were no significant changes in the area of necrosis, head collapse, and articular space at the latest follow-up compared with those before operation (P<0.05) . [Conclusion] This head-neck fenestration bone autografting through DAA still achieves acceptable clini- cal outcomes for the pericollapse-stage femoral head necrosis