Abstract:[Objective] To investigate the effects of sagittal configuration related anatomical morphology parameters of lateral femoral condyle on anterior cruciate ligament (ACL) injury. [Methods] A retrospective study was conducted on 100 patients who received knee ar- throscopic surgery from January 2017 to January 2020. Of them, 50 patients had ACL injury (the injury group) and 50 patients had simple meniscus injury (the control group) . The lateral femoral condylar index (LFCI) and the posterior condylar ratio of lateral femoral condyle were measured and compared between the two groups, while ROC analysis was performed for ACL injury. [Results] The posterior condyle diameter and LFCI of the injured group were significantly lower than those of the control group (P<0.05) , but there was no significant differ- ence in anterior condyle diameter between the two groups (P>0.05) . The distal femoral diameter of the injured group was larger than that of the control group (P<0.05) , but the posterior condylar ratio of the injured group was significantly smaller than that of the control group (P< 0.05) , and there was no statistically significant difference in the posterior condyle eccentricity between the two groups (P>0.05) . As results of ROC analysis, the area under curve (AUC) of LFCI and posterior condylar ratio of lateral femur condyle were 0.717 and 0.713, respective- ly. [Conclusion] LFCI and posterior condylar ratio of the lateral femoral condyle might be regarded as predictors of ACL injury.