PI3K/AKT信号通路在非创伤股骨头坏死的作用△

Role of PI3K / Akt signaling pathway in non-traumatic necrosis of femoral head

摘要:

非创伤性股骨头坏死(nontraumatic osteonecrosis of the femoral head, NONFH)是临床常见的骨科疾病，而血液循环障碍则是导致 NONFH 的主要病因之一，所以改善血液循环对 NONFH 的早中期阶段的预防和治疗具有重要的意义。多个信号通路都可以通过改善血液循环对 NONFH 起到防治作用，包括 PI3K/AKT 作为其中重要的信号通路可以通过调控上下游因子来改善血液循环，从而达到预防和治疗 NONFH 的作用。本文主要讨论 PI3K/AKT 信号通路通过影响导致血液循环障碍的众多因素 (例如脂代谢紊乱和血管再生等方面) 防治 NONFH 进行综述。通过影响血管内皮生长因子、P2Y12 受体和一氧化氮合成酶等上下游因子调整和改善血液循环，从而为 NONFH 防治提供新的参考及依据。

Abstract:

Nontraumatic osteonecrosis of the femoral head (NONFH) is a common clinical orthopaedic disease, while blood circulation impairment has been considered as one of the main reasons of this disorder. Therefore, improving blood circulation is of great significance for the prevention and treatment of NONFH in the early and middle stages. Multiple signal pathways might prevent and treat NONFH by im- proving blood circulation, including PI3K/Akt signal pathway. This paper mainly discusses the role of PI3K/Akt signaling pathway in affect- ing NONFH by many factors related to blood circulation, such as lipid metabolism disorder and vascular regeneration. In addition, PI3K/ Akt signaling pathway might improve blood circulation by affecting upstream and downstream factors such as vascular endothelial growth factor, P2Y12 receptor and nitric oxide synthase, so as to provide a new reference and basis for the prevention and treatment of NONFH.