Abstract:[Objective] To explore the clinical outcomes of V-Y advanced flap combined with reversed dorsal digital artery island flap for repairing degloving injury or amputation of distal thumb. [Methods] From March 2017 to August 2019, 23 patients were surgically treat- ed for degloving injury or amputation of distal thumb without indication of replantation. Of them, 10 patients had traumatic amputation, while 13 patients were of degloving injury of distal thumbs. V-Y advanced flap combined with a reversed dorsal digital artery island flap was used to repair the volar and dorsal defects of distal thumb respectively, with direct closure of donor-site defects of the two flaps. [Results] All flaps survived uneventfully in the 23 patients. The follow-up period lasted from 8 to 18 months with an average of (12.30±2.46) months. The appearance of the distal thumbs looked good, without pain and cold intolerance at the fingertip of the thumb, whereas only lin- ear scars were remained at donor site of the dorsal thumb in all the patients. The static 2-point discrimination of the V-Y advanced flap and reversed dorsal digital artery island flap ranged from 4 to 7 mm and 5 to 9 mm respectively. There was no statistical difference of the to- tal range of motion between the injured and healthy thumbs (P>0.05) . Based on the criteria of the hand appearance evaluation, 15 patients were satisfied very much, and 8 patients were satisfied. [Conclusion] The V-Y advanced flap combined with reversed dorsal digital artery island flap is a good option for repairing degloving injury or amputation of distal thumb, with advantages of simple operation, less donor-site morbidity and satisfactory clinical results.