Abstract:[Objective] To introduce the surgical and nursing techniques, as well as preliminary clinical outcomes of Nice self-locking slide-suture stretching for delayed closure of skin and soft tissue defects. [Methods] Abovementioned techniques were used in 32 patients who suffered from skin and soft tissue defects secondary to traumatic skin necrosis, tension-reduction incision, skin scar resection and oth- er reasons. Based on characteristics of the skin viscoelasticity and creep of the extension, the Nice self-locking of slide suture system was set up by high tension suture in double bundles with interrupted skin suture and tied by the Nice knot. Firstly, the loop side of the wire was wound to the end side wire to form an ascending single knot, and tightened, and then, the end of the wire was threaded through the loop, and the double ends were separated. As the knot was tightened, the skin edges were close to each other. According to the skin blood supply, the suture knot was gradually tightened, the skin defect wound was delayed closed by the stretching, simultaneously, the perioperative period care and rehabilitation were conducted. The wound healing, as well as skin sensation, color, tension and hair growth were evaluated. [Re- sults] All the wounds in the 32 patients were closed in 2~4 weeks. The skin regained the normal sensation and the color with well hair growth and elasticity, whereas without obvious edema and scar hyperplasia. [Conclusion] Nice self-locking slide-suture stretching tech- nique is a simple, economical and effective treatment for delayed closure of skin defect wounds.