Abstract:[Objective] To compare the clinical results of locking plate (LP) versus retrograde intramedullary nailing (RIMN) for distal femur fractures. [Methods] From January 2018 to November 2019, 100 patients with distal femur fractures were enrolled in this study and underwent open reduction and internal fixation. According to preoperative doctor-patient communication results, 50 patients were treated with LP, while the remaining 50 were with RIMN. The perioperative, follow-up and imaging data were compared between the two groups. [Results] All patients in both groups had operation completed successfully without serious complications. The RIMN group proved signifi- cantly superior to the LP group in terms of operation time, incision length, intraoperative blood loss, postoperative drainage volume and hos- pital stay (P<0.05) . However, there were no significant differences in the number of intraoperative fluoroscopy and wound healing between the two groups (P>0.05) . All the patients in both groups were followed up for more than 12 months. The RIMN group resumed walking and full weight-bearing activity significantly earlier than the LP group (P<0.05) . The VAS scores decreased significantly (P<0.05) , whereas the knee extension-flexion range of motion (ROM) and HSS score increased significantly in both groups over time postoperatively (P<0.05) . At the corresponding postoperative time point, there was no significant difference in VAS score between the two groups (P>0.05) , but the RIMN group proved significantly superior to the LP group in terms of ROM and HSS score (P<0.05) . Radiographically, there was no signifi- cant difference in fracture reduction quality between the two groups (P<0.05) , however, the RIMN group got fracture healing on images sig- nificantly earlier than the LP group (P<0.05) . [Conclusion] The retrograde intramedullary nailing for internal fixation of distal femoral frac- tures has advantages of less trauma and better postoperative functional recovery over the locking plate.