Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of double cutaneous nerves anastomosed lo- cal pedicle flap for repair of thumb defect. [Methods] From May 2018 to June 2020, a total of 20 patients received double cutaneous nerves anastomosed pedicle flap for repair of thumb tip or palmar defects. After debridement, the flap was designed according to the size and loca- tion of tissue defect. The proximal edge of the flap was firstly cut to expose the terminal branches of superficial radial nerve and the termi- nal ramus of the lateral cutaneous nerve of the forearm. As harvesting the flap, the 2 cutaneous nerves were labelled and cut off sharply with preservation of their distribution in the flap, which had vascular pedicle of subcutaneous fascia tissue about wide 1.0 cm retained. The flap was transferred to cover the distal wound by an open tunnel. Subsequently, the two cutaneous nerves were anastomosed end-to-end with the stumps of two digital nerves under microscope. The flap donor site was sutured directly. [Results] All the 20 patients had the flap sur- vived, and followed up for (12.20±1.70) months. At the last follow-up, all the patients got the thumb in nice appearance, and only linear scar remained in the radial donor area. The static two-point discrimination of the flap ranged from 4 to 8 mm, with an average of (6.25± 0.91) mm. [Conclusion] Compared with pedicle flap innervated by a single cutaneous nerve, this double-nerve-anastomosed local pedicle flap, including terminal branches of superficial radial nerve and the terminal ramus of the lateral cutaneous nerve of the forearm, is a feasi- ble technique for repair of the thumb defect, should be conducive to sensory recovery