Abstract:[Objective] To evaluate the clinical efficacy of endoscope-assisted transforaminal lumbar interbody fusion (MIS-TLIF) for single-level lumbar disc herniation with functional scoliosis. [Methods] A retrospective study was conducted on 51 patients who underwent surgical treatment for single-level lumbar disc herniation with functional scoliosis from June 2014 to December 2020. According to doctorpatient communication, 20 patients received MIS- TLIF (the MIS group) , while the other 31 patients underwent open TLIF (the open group) . The clinical and imaging data of the two groups were compared. [Results] All patients in both groups had operation completed suc- cessfully without serious complications. The MIS group proved significantly superior to the open group in terms of intraoperative bleeding, incision length and hospital stay (P<0.05) . As time went during the follow-up lasted for (19.55±4.28) months, the VAS scores for lumbar and leg pain, as well as ODI score in both groups significantly decreased (P<0.05) , whereas which were not statistically significant between the two groups at any corresponding time points (P>0.05) . Radiographically, the scoliotic Cobb angle significantly decreased (P<0.05) , while the height of intervertebral space and L1~S1 lordotic angle significantly increased in both groups at the latest follow-up compared with those preoperatively (P<0.05) . [Conclusion] This endoscope-assisted TLIF has advantages of smaller surgical incision, less intraoperative bleeding, and shorter hospital stay over the open TLIF for single-level lumbar disc herniation with functional scoliosis.