Abstract:[Objective] To explore the outcomes of predictive nursing based on Caprini risk assessment for deep venous thrombosis (DVT) after surgical treatment of lower extremity fractures. [Methods] From December 2020 to May 2022, 90 patients with lower extremity fractures were enrolled in this study. They were divided into two groups using random number table method, including 46 patients who were given predictive care (PC) based on Caprini risk assessment and 44 patients who received routine care (RC) . The documents of clinical evaluation, laboratory test and ultrasonic examination were compared between the two groups. [Results] All patients in both groups were successfully operated on without serious intraoperative complications. The PC group was significantly better than the RCl group in terms of VAS score 3 days postoperatively, hospital stay and incidence of early onset complications (P<0.05) . In terms of laboratory tests, the PC group had significantly longer PT and aPTT, while significantly lower PLT and Fbg than the RC group at 7 days postoperatively (P<0.05) . In addition, the PC group had significantly lower D-D, PIC and TAT than RC group 7 days postoperatively (P<0.05) . In terms of ultrasonog- raphy, the incidence of DVT at 3 days after surgery was of 4/46 (8.70%) in the PC group, whereas 11/44 (25.00%) in the RC group (P= 0.002) , with lower limb venous blood stream velocity of (25.26±3.58) cm/s in the PC group than (22.34±2.24) cm/s in the RC group (P< 0.001) . [Conclusion] Predictive nursing based on Caprini risk assessment after surgical treatment of lower extremity fractures does relieve postoperative hypercoagulability state, decline thrombotic molecular markers and occurrence of DVT, reduce complications and is benefit to patients' postoperative recovery.