Abstract:[Objective] To evaluate the clinical outcomes of single intramedullary Kirschner wire for fixation of re-fracture of the fifth metacarpal neck secondary to primary internal fixation. [Methods] From January 2015 to June 2021, 10 patients received internal fixa- tion with a single 2.0 mm intramedullary Kirschner wire for re-fracture of the fifth metacarpal neck. The perioperative, follow-up and imag- ing data were summarized. [Results] All studied patients had operation completed successfully with operation time of (18.60±2.88) min, whereas without serious complications such as reduction loss, infection, bone nonunion, tendon stimulation and joint stiffness. As time went in follow-up lasted for 3~6 months with a mean of (4.90±1.10) months, VAS and DASH scores, as well as metacarpophalangeal range of mo- tion (ROM) significantly improved (P<0.05) . Radiographically, the excellent fracture reduction at 3 months after operation and the last fol- low-up was 90%, additionally, fracture healing achieved in 40% at 3 months, while 100% at the last follow-up (P<0.05) . [Conclusion] The single intramedullary Kirschner wire fixation for re-fracture of fifth metacarpal neck does achieve satisfactory clinical consequences.